The “big 10” has a stout reputation among Alaskan bear guides and hunters for its stopping power. The most powerful factory-loaded handgun cartridge that still fits into a service pistol-sized semiauto is the 10mm. But when you’re headed into the backcountry (or live there), the 10mm is ideal for a variety of hunting pursuits and to defend yourself from both animal and human predators. Now, this handgun will likely never be an everyday carry gun in an urban setting (it’s not exactly a dainty pistol). 357 hand cannon for self-defense, the 10mm is the perfect option. If you want a pistol that can take down a mountain lion but is also easier to carry than a.